Competence of the organizing groups

Bioprocess Engineering Laboratory (BPEL), Prof. Peter Neubauer

BPEL focuses on new technologies for fast and parallel bioprocess development. Aside from breakthroughs in protein production (e.g. Wnt proteins and collagen prolyl-4-hydroxylase), it has developed key tools, such as Senbit^® and Enbase^TM (www.biosilta.com). BPEL is also a renowned laboratory for the scale-up of recombinant bioprocesses. In the area of biocatalysis, BPEL currently focuses on directed evolution of enzymes for new catalytic activities.

Websites:

www.oulu.fi/bioprocess

Selected papers:

Ruottinen et al. Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system. BMC Biotechnol. 8 33, 2008.
Casteleijn et al. The functional role of the conserved active site proline of triosephosphate isomerase. Biochem. 45, 15483 - 15494, 2008.
Vasala et al. A new wireless system for decentralised measurement of physiological parameters from shake flasks. Microb. Cell Fact. 5, 8, 2006.
Fahnert et al. Murine Wnt-1 with an internal c-myc-tag recombinantly produced in Escherichia coli can induce intracellular signaling of the canonical Wnt pathway in eukaryotic cells. J. Biol. Chem. 279 (46), 47520-47527, 2004.